Open AccessNeoadjuvant peptide receptor radionuclide therapy for aninoperable neuroendocrine pancreatic tumor
Author(s) -
Daniel Kaemmerer,
Vinay Prasad,
Wolfgang Daffner,
Dieter Hörsch,
Günter Klöppel,
Merten Hommann,
R. P. Baum
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.5867
Subject(s) - radionuclide therapy , peptide receptor , medicine , neuroendocrine tumors , endocrine system , pancreatic tumor , neoadjuvant therapy , oncology , pancreas , pancreatic cancer , receptor , cancer , hormone , breast cancer
Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen. At diagnosis many of them are already advanced and difficult to treat. We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman, who received neoadjuvant peptide receptor radionuclide therapy (PRRT) as first-line treatment. This resulted in a significant downstaging of the tumor and allowed its subsequent complete surgical removal. Follow-up for eighteen months revealed a complete remission. This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection.