Open AccessBiomarkers for noninvasive biochemical diagnosis of nonalcoholic steatohepatitis: Tools or decorations?
Author(s) -
Yusuf Yılmaz,
Enver Dolar
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.4346
Subject(s) - nonalcoholic fatty liver disease , nonalcoholic steatohepatitis , medicine , liver biopsy , steatohepatitis , fatty liver , identification (biology) , disease , surrogate endpoint , liver disease , biopsy , intensive care medicine , pathology , gastroenterology , bioinformatics , biology , botany
In light of the growing epidemics of nonalcoholic fatty liver disease (NAFLD), identification and validation of the novel biochemical surrogate markers for nonalcoholic steatohepatitis (NASH) are paramount to reduce the necessity for liver biopsy. The availability of such markers has tremendous potential to radically alter the management strategies of NAFLD patients and to monitor the disease activity. Although current biomarkers do not entirely fulfill the many requirements for the identification of patients with NASH, they should not discourage our quest, but remind us that we need to cognize the challenges ahead.