Open AccessCombined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia
Author(s) -
Inneke Willekens,
Anne Hoorens,
Caroline Geers,
Bart Op de Beeck,
Frederik Vandenbroucke,
Johan De Mey
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.3940
Subject(s) - hepatocellular carcinoma , focal nodular hyperplasia , medicine , magnetic resonance imaging , pathology , carcinoma , radiology
Combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed. Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHCC-CC in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging. Correlation of imaging and serum levels of alpha-fetoprotein and CA19.9 can help to make the correct diagnosis preoperatively.