Open AccessIL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location
Author(s) -
Rocío Sánchez,
Émile Lévy,
Florin Costea,
Daniel Sinnett
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.3776
Subject(s) - haplotype , genotype , genotyping , allele , biology , crohn's disease , genetics , glucocorticoid receptor , immunology , gene , disease , medicine
To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-alpha and the interleukin (IL)-10 in childhood Crohn's disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.