Open AccessFulminant amoebic colitis during chemotherapy for advanced gastric cancer
Author(s) -
Noboru Hanaoka,
Katsuhiko Higuchi,
Satoshi Tanabe,
Takeshi Sasaki,
Kenji Ishido,
Takako Ae,
Wasaburo Koizumi,
Katsunori Saigenji
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.3445
Subject(s) - medicine , gastroenterology , chemotherapy , cancer , metronidazole , colitis , fulminant , peritonitis , perforation , surgery , antibiotics , materials science , metallurgy , microbiology and biotechnology , punching , biology
A 52-year-old man had bloody stools during chemotherapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis with intestinal perforation developed, and emergency peritoneal lavage and colostomy were performed. After surgery, endotoxin adsorption therapy was performed and metronidazole was given. Symptoms of peritonitis and colonitis resolved. However, the patient's general condition worsened with the progression of gastric cancer. The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy.