Open AccessCD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract
Author(s) -
Ellen J. Beswick,
Victor E. Reyes
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.2855
Subject(s) - cd74 , macrophage migration inhibitory factor , proinflammatory cytokine , inflammation , immunology , helicobacter pylori , gastrointestinal tract , biology , cancer , medicine , antigen , cytokine , cancer research , mhc class ii , major histocompatibility complex
CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.