CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract | Zendy

Ellen J. Beswick | Zendy; Victor E. Reyes | Zendy

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CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Author(s) -

Ellen J. Beswick,

Victor E. Reyes

Publication year - 2009

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.15.2855

Subject(s) - cd74 , macrophage migration inhibitory factor , proinflammatory cytokine , inflammation , immunology , helicobacter pylori , gastrointestinal tract , biology , cancer , medicine , antigen , cytokine , cancer research , mhc class ii , major histocompatibility complex

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

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