Open AccessBreastfeeding and genetic factors in the etiology of inflammatory bowel disease in children
Author(s) -
Theresa A. Mikhailov,
Sylvia E. Furner
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.270
Subject(s) - etiology , inflammatory bowel disease , medicine , breastfeeding , nod2 , disease , inflammatory bowel diseases , gastrointestinal tract , crohn's disease , ulcerative colitis , gastroenterology , immunology , pediatrics
Inflammatory bowel disease is a chronic, debilitating disorder of the gastrointestinal tract. The etiology of inflammatory bowel disease has not been elucidated, but is thought to be multifactorial with both environ-mental and genetic influences. A large body of research has been conducted to elucidate the etiology of inflammatory bowel disease. This article reviews this literature, emphasizing the studies of breastfeeding and the studies of genetic factors, particularly NOD2 polymorphisms.