Open AccessEmerging clinical and therapeutic applications of Nigella sativa in gastroenterology
Author(s) -
Shailendra Kapoor
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.2170
Subject(s) - nigella sativa , azoxymethane , lipid peroxidation , carbon tetrachloride , ccl4 , dna damage , pharmacology , medicine , insulin , carcinogenesis , chemistry , oxidative stress , biochemistry , traditional medicine , cancer , dna , organic chemistry
Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.