Open AccessBile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation
Author(s) -
Barbara Renga,
Andrea Mencarelli,
Marco Migliorati,
Eleonora Distrutti,
Stefano Fiorucci
Publication year - 2009
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.15.2097
Subject(s) - farnesoid x receptor , chenodeoxycholic acid , bile acid , chemistry , microbiology and biotechnology , gene expression , nuclear receptor , reporter gene , biochemistry , medicine , endocrinology , biology , gene , transcription factor
To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfide (H(2)S) generation.