Open AccessMLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families
Author(s) -
HuanXiang Zhou,
Yan Shi,
Xiao Zhou,
Du Xiang,
Tai Ming Zhang,
Xu Cai,
Yegang Lu,
San Jun Cai,
Da Shi
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.7329
Subject(s) - mlh1 , biology , genetics , germline mutation , msh2 , msh6 , microsatellite instability , methylation , germline , cancer research , mutation , gene , dna mismatch repair , cancer , colorectal cancer , microsatellite , allele
To detect the MLH1 gene promoter germline-methylation in probands of Chinese hereditary nonpolyposis colorectal cancer (HNPCC), and to evaluate the role of methylation in MLH1 gene promoter and molecular genetics in screening for HNPCC.