MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families | Zendy

Heng-Hua Zhou | Zendy; Shi-Yan Yan | Zendy; Xiao-Yan Zhou | Zendy; Du Xiang | Zendy; Tai-Ming Zhang | Zendy; Cai Xu | Zendy; Yong-Ming Lu | Zendy; San-Jun Cai | Zendy; Da-Ren Shi | Zendy

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MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families

Author(s) -

Heng-Hua Zhou,

Shi-Yan Yan,

Xiao-Yan Zhou,

Du Xiang,

Tai-Ming Zhang,

Cai Xu,

Yong-Ming Lu,

San-Jun Cai,

Da-Ren Shi

Publication year - 2008

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.14.7329

Subject(s) - mlh1 , biology , genetics , germline mutation , msh2 , msh6 , microsatellite instability , methylation , germline , cancer research , mutation , gene , dna mismatch repair , cancer , colorectal cancer , microsatellite , allele

To detect the MLH1 gene promoter germline-methylation in probands of Chinese hereditary nonpolyposis colorectal cancer (HNPCC), and to evaluate the role of methylation in MLH1 gene promoter and molecular genetics in screening for HNPCC.

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