Methotrexate induced sprue-like syndrome | Zendy

Marta Maia Boscá-Watts | Zendy; R Añón | Zendy; Émpar Mayordomo | Zendy; Rosana Villagrasa | Zendy; Nelly Balza | Zendy; Cirilo Amorós | Zendy; Juan Ramon Corts | Zendy; A Benages | Zendy

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Methotrexate induced sprue-like syndrome

Author(s) -

Marta Maia Boscá-Watts,

R Añón,

Émpar Mayordomo,

Rosana Villagrasa,

Nelly Balza,

Cirilo Amorós,

Juan Ramon Corts,

A Benages

Publication year - 2008

Publication title -

world journal of gastroenterology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.14.7009

Subject(s) - medicine , methotrexate , gastroenterology , sprue , iron deficiency anemia , anemia , villous atrophy , endoscopy , iron deficiency , surgery , coeliac disease , mold , genetics , disease , biology

A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administering intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.

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