Open AccessMethotrexate induced sprue-like syndrome
Author(s) -
M Boscá,
R Añón,
Émpar Mayordomo,
Rosana Villagrasa,
Nelly Balza,
Cirilo Amorós,
Juan Ramon Corts,
A Benages
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.7009
Subject(s) - medicine , methotrexate , gastroenterology , sprue , iron deficiency anemia , anemia , villous atrophy , endoscopy , iron deficiency , surgery , coeliac disease , mold , genetics , disease , biology
A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administering intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.