Open AccessInhibitory effect of interferon-α-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice
Author(s) -
Bin Cao,
Xiaoping Chen,
Ping Zhu,
Lei Ding,
Jian Guan,
Zuo-Liang Shi
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.6802
Subject(s) - hepatocellular carcinoma , vascular endothelial growth factor , angiogenesis , apoptosis , tunel assay , alpha interferon , western blot , nude mouse , immunohistochemistry , medicine , alpha (finance) , cyclooxygenase , interferon , endocrinology , biology , immunology , vegf receptors , cancer , enzyme , gene , biochemistry , construct validity , nursing , patient satisfaction
To evaluate the effects of interferon-alpha-2b (IFN-alpha-2b) on expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human hepatocellular carcinoma (HCC) inoculated in nude mice and to study the underlying mechanism of IFN-alpha-2b against HCC growth.