Open AccessSolitary fibrous tumor of the liver expressing CD34 and vimentin: A case report
Author(s) -
Dimitris P. Korkolis,
Katerina Apostolaki,
Chrysanthi Aggeli,
George A. Plataniotis,
Emmanuel Gontikakis,
Dimitra Volanaki,
Maria Sebastiadou,
Dimitrios Dimitroulopoulos,
Dimitrios Xinopoulos,
George Zografos,
P. Vassilopoulos
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.6261
Subject(s) - solitary fibrous tumor , vimentin , cd34 , medicine , pathology , hepatectomy , palpation , immunohistochemistry , lesion , stroma , radiology , resection , surgery , biology , genetics , stem cell
A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported. An 82-year-old female presented with left upper abdominal discomfort, a firm mass on palpation, and imaging studies revealed a large tumor, 15 cm in diameter, arising from the left lobe of the liver. A formal left hepatectomy was performed. Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma. Immunohistochemistry disclosed diffuse CD34 and positive vimentin, supporting the diagnosis of a benign SFT. The patient remained well 21 months after surgery. SFT of the liver is a very rare neoplasm of mesenchymal origin. In most cases it is a benign lesion, although some may have malignant histological features and recur locally or metastasize. With less than 30 reported cases in the literature, little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy. Complete surgical resection remains the cornerstone of its treatment.