Open AccessSildenafil does not influence hepatic venous pressure gradient in patients with cirrhosis
Author(s) -
J Clemmesen,
Annamaria Giraldi,
Peter Ott,
Kim Dalhoff,
Bent Adel Hansen,
Fin Stolze Larsen
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.6208
Subject(s) - medicine , sildenafil , portal venous pressure , cirrhosis , splanchnic , portal hypertension , blood pressure , blood flow , liver disease , splanchnic circulation , anesthesia , cardiology , gastroenterology
To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient (HVPG) in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown.