Open AccessRegulation of demethylation and re-expression of RASSF1A gene in gastric cancer cell lines by combined treatment of 5-Aza-CdR and NaB
Author(s) -
Wei Shen,
DongQiu Dai,
Yue Teng,
Hongbo Liu
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.595
Subject(s) - microbiology and biotechnology , methylation , dna methylation , gene expression , biology , demethylation , histone deacetylase inhibitor , promoter , gene , epigenetics , regulation of gene expression , cancer research , histone deacetylase , histone , genetics
To investigate the changes of methylation state and expression of RASSF1A gene in human gastric cancer cell lines SGC7901 and BGC823 which were treated in vitro with demethlylating agent 5-Aza-CdR in combination with histone deacetylase inhibitor NaB.