Open AccessDevelopment of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report
Author(s) -
Atsushi Takahashi,
Yukiko Kanno,
Yuta Takahashi,
Natsumi Sakamoto,
Kyoko Monoe,
Hironobu Saito,
Kazumichi Abe,
Junko Yokokawa,
Atsushi Irisawa,
Hiromasa Ohira
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.5474
Subject(s) - medicine , methylprednisolone , autoimmune hepatitis , multiple sclerosis , hepatitis , gastroenterology , ataxia , immunology , psychiatry
A 43-year-old woman with multiple sclerosis (MS) was treated with pulsed methylprednisolone and interferon beta at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis (AIH). She was successfully treated with corticosteroids. As ataxia developed after 1 year, she was treated with pulsed methylprednisolone for 3 d, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.