Open AccessRoscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells
Author(s) -
Mohamed-Salah I. Abaza,
Abdul-Majeed Bahman,
Rajaa AlAttiyah
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.5162
Subject(s) - apoptosis , doxorubicin , cell cycle , colorectal cancer , biology , pharmacology , cancer , chemotherapy , biochemistry , genetics
To examine the ability of cyclin-dependent kinase inhibitor (CDKI) roscovitine (Rosco) to enhance the antitumor effects of conventional chemotherapeutic agents acting by different mechanisms against human colorectal cancer.