Open AccessRecurrence of cholestatic liver disease after living donor liver transplantation
Author(s) -
Sumihito Tamura,
Yasuhiko Sugawara,
Junichi Kaneko,
Junichi Togashi,
Yuichi Matsui,
Noriyo Yamashiki,
Norihiro Kokudo,
Masatoshi Makuuchi
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.5105
Subject(s) - medicine , liver transplantation , primary sclerosing cholangitis , primary biliary cirrhosis , liver disease , transplantation , gastroenterology , cirrhosis , disease
End-stage liver disease, due to cholestatic liver diseases with an autoimmune background such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), is considered a good indication for liver transplantation. Excellent overall patient and graft outcomes, based mostly on the experience from deceased donor liver transplantation (DDLT), have been reported. Due to the limited number of organ donations from deceased donors in most Asian countries, living donor liver transplantation (LDLT) is the mainstream treatment for end-stage liver disease, including that resulting from PBC and PSC. Although the initial experiences with LDLT for PBC and PSC seem satisfactory or comparable to that with DDLT, some aspects, including the timing of transplantation, the risk of recurrent disease, and its long-term clinical implications, require further evaluation. Whether or not the long-term outcomes of LDLT from a biologically related donor are equivalent to that of DDLT requires further observations. The clinical course following LDLT may be affected by the genetic background shared between the recipient and the living related donor.