Open AccessVanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus
Author(s) -
Gökhan Okan,
Serpil Yaylacı,
Önder Peker,
Sabahattin Kaymakoğlu,
Murat Saruç
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.4697
Subject(s) - cholestasis , medicine , tacrolimus , ciprofloxacin , disease , drug , gastroenterology , pharmacology , antibiotics , transplantation , microbiology and biotechnology , biology
Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.