Open AccessLack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
Author(s) -
Ayhan Koyuncu,
İhsan Bağcıvan,
Bülent Saraç,
Cengiz Aydın,
Seda Yıldırım,
Yusuf Sarıoğlu
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.4667
Subject(s) - sodium nitroprusside , isosorbide dinitrate , internal anal sphincter , nitric oxide , chemistry , sphincter , muscle relaxation , incubation , endocrinology , medicine , anatomy , biochemistry , rectum , anal canal
To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitroprusside (SNP) in internal anal sphincter (IAS) smooth muscle.