Open AccessClinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease
Author(s) -
Luciana Rigoli,
Claudio Romano,
Rosario Alberto Caruso,
M.A. Lo Presti,
Chiara Di Bella,
V. Procopio,
Lo Giudice G,
Maria Amorini,
Giuseppe Costantino,
M.D. Sergi,
Caterina Cuppari,
Giovanna Elisa Calabrò,
Romina Gallizzi,
Carmelo Salpietro,
Walter Fries
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.4454
Subject(s) - nod2 , single nucleotide polymorphism , inflammatory bowel disease , genotype , ulcerative colitis , crohn's disease , allele frequency , snp , gastroenterology , allele , medicine , immunology , biology , disease , genetics , gene
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.