Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate | Zendy

Seiji Suzuki | Zendy; Koji Sasajima | Zendy; Masayuki Miyamoto | Zendy; Hidehiro Watanabe | Zendy; Tadashi Yokoyama | Zendy; Hiroshi Maruyama | Zendy; Takeshi Matsutani | Zendy; Aimin Liu | Zendy; Masaru Hosone | Zendy; Shotaro Maeda | Zendy; Takashi Tajiri | Zendy

Open Access

Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate

Author(s) -

Seiji Suzuki,

Koji Sasajima,

Masayuki Miyamoto,

Hidehiro Watanabe,

Tadashi Yokoyama,

Hiroshi Maruyama,

Takeshi Matsutani,

Aimin Liu,

Masaru Hosone,

Shotaro Maeda,

Takashi Tajiri

Publication year - 2008

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.14.3763

Subject(s) - gist , medicine , imatinib mesylate , magnetic resonance imaging , stromal tumor , gastrectomy , biopsy , hepatectomy , metastasis , imatinib , stromal cell , stomach , radiology , gastroenterology , surgery , pathology , cancer , resection , myeloid leukemia

A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.

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