Open AccessPathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate
Author(s) -
Seiji Suzuki,
Koji Sasajima,
Masayuki Miyamoto,
Hidehiro Watanabe,
Tadashi Yokoyama,
Hiroshi Maruyama,
Takeshi Matsutani,
Aimin Liu,
Masaru Hosone,
Shotaro Maeda,
Takashi Tajiri
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.3763
Subject(s) - gist , medicine , imatinib mesylate , magnetic resonance imaging , stromal tumor , gastrectomy , biopsy , hepatectomy , metastasis , imatinib , stromal cell , stomach , radiology , gastroenterology , surgery , pathology , cancer , resection , myeloid leukemia
A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.