Open AccessInhibitory effect of dimeric β peptide on the recurrence and metastasis of hepatocellular carcinoma in vitro and in mice
Author(s) -
Songmei Wang,
Jun Zhu,
Luan-Feng Pan,
Yinkun Liu
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.3054
Subject(s) - hepatocellular carcinoma , metastasis , matrigel , cancer research , extracellular matrix , fibronectin , cell culture , cancer cell , in vitro , adhesion , medicine , carcinoma , cell adhesion , cancer , mtt assay , pathology , chemistry , biology , angiogenesis , biochemistry , organic chemistry , genetics
To block the adhesion of tumor cells to the extracellular matrix, and prevent tumor metastasis and recurrence, the dimer of the beta peptide (DLYYLMDLSYSMKGGDLYYLMDLSYSMK, beta2) was designed and synthesized and its anti-adhesion and anti-invasion effects on hepatocellular carcinoma cells were assessed. Additionally, its influence on the metastasis and recurrence of mouse hepatocellular carcinoma was measured.