Open AccessDown-regulation of transforming growth factor β1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 is related to deactivation of LX-2 cells
Author(s) -
Li Li,
Xinyan Zhao,
Bao-en Wang
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2894
Subject(s) - microbiology and biotechnology , activin receptor , tgf beta receptor 2 , transforming growth factor beta , signal transduction , receptor , transforming growth factor , gene expression , phosphorylation , acvrl1 , kinase , tgf beta signaling pathway , chemistry , biology , cell culture , endoglin , gene , growth factor , tgf alpha , biochemistry , genetics , stem cell , cd34
To investigate the effect of herbal compound 861 (Cpd861) on the transforming growth factor-beta1 (TGF beta 1)/activin receptor-like kinase 1 (ALK1, type I receptor) signaling-pathway-related gene expression in the LX-2 cell line, and the inhibitory mechanism of Cpd861 on the activation of LX-2 cells.