Open AccessEffect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats
Author(s) -
Shintaro Fukushima,
Hiroyasu Okuno,
Nobuyuki Shibatani,
Yoshitsugu Nakahashi,
Toshihito Seki,
Kazuichi Okazaki
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2556
Subject(s) - isozyme , medicine , bile duct , cytochrome p450 , biliary drainage , gastroenterology , biliary tract , jaundice , common bile duct , biology , endocrinology , metabolism , biochemistry , enzyme
To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice.