Open AccessInhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro
Author(s) -
Jikun Li,
Yu Lan,
Yun Shen,
Lisheng Zhou,
Yicheng Wang,
Jianhai Zhang
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2308
Subject(s) - metastasis , cancer research , colorectal cancer , cell culture , matrix metalloproteinase , cell growth , cxcr4 , viability assay , cancer cell , vascular endothelial growth factor , cell migration , chemotaxis , chemokine receptor , chemistry , biology , cancer , chemokine , receptor , medicine , vegf receptors , biochemistry , genetics
To investigate the effect and mechanism of blockade of the CXC chemokine receptor-4 (CXCR4) signaling pathway by AMD3100, a small non-peptide CXCR4 inhibitor, on invasion and metastasis of colorectal cancer cells in vitro.