Open AccessExpression of thymidine kinase mediated by a novel non-viral delivery system under the control of vascular endothelial growth factor receptor 2 promoter selectively kills human umbilical vein endothelial cells
Author(s) -
Ying Wang,
Hui-Xiong Xu,
Ming-De Lu,
Qing Tang
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.224
Subject(s) - transfection , microbiology and biotechnology , umbilical vein , thymidine kinase , kinase insert domain receptor , genetic enhancement , biology , gene delivery , green fluorescent protein , recombinant dna , vascular endothelial growth factor , cell culture , vascular endothelial growth factor a , cancer research , virology , gene , in vitro , biochemistry , virus , herpes simplex virus , genetics , vegf receptors
To investigate the killing efficiency of a recombinant plasmid containing a thymidine kinase (TK) domain insert driven by the vascular endothelial growth factor receptor 2 (VEGFR2) promoter (KDR) on vascular endothelial cells.