Pharmacokinetics and tissue distribution of intraperitoneal 5-fluorouracil with a novel carrier solution in rats | Zendy

Zhigang Wei | Zendy; Guoxin Li | Zendy; Xiang-cheng Huang | Zendy; Zhen Li | Zendy; Yu Jiang | Zendy; Haijun Deng | Zendy; Shan-Hua Qing | Zendy; Ce Zhang | Zendy

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Pharmacokinetics and tissue distribution of intraperitoneal 5-fluorouracil with a novel carrier solution in rats

Author(s) -

Zhigang Wei,

Guoxin Li,

Xiang-cheng Huang,

Zhen Li,

Yu Jiang,

Haijun Deng,

Shan-Hua Qing,

Ce Zhang

Publication year - 2008

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.14.2179

Subject(s) - pharmacokinetics , saline , hydroxyethyl starch , peritoneal fluid , peritoneal cavity , peritoneal dialysis , sodium , chemistry , intraperitoneal injection , fluorouracil , distribution (mathematics) , fluid compartments , volume of distribution , extracellular fluid , endocrinology , pharmacology , medicine , chemotherapy , biochemistry , surgery , mathematical analysis , mathematics , organic chemistry , extracellular

To compare the pharmacokinetics and tissue distribution of 5-fluorouracil administered intraperitoneally with two isotonic carrier solutions: HAES-steri (neotype 6% hydroxyethyl starch), a novel carrier solution with middle molecular weight and physiologic saline (0.9% sodium chloride solution), a traditional carrier solution for intraperitoneal chemotherapy, in rats.

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