Open AccessPharmacokinetics and tissue distribution of intraperitoneal 5-fluorouracil with a novel carrier solution in rats
Author(s) -
Zhigang Wei,
Guoxin Li,
Xiaofeng Huang,
Zhen Li,
Yu Jiang,
Haijun Deng,
Shan-Hua Qing,
Ce Zhang
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2179
Subject(s) - pharmacokinetics , saline , hydroxyethyl starch , peritoneal fluid , peritoneal cavity , peritoneal dialysis , sodium , chemistry , intraperitoneal injection , fluorouracil , distribution (mathematics) , fluid compartments , volume of distribution , extracellular fluid , endocrinology , pharmacology , medicine , chemotherapy , biochemistry , surgery , mathematical analysis , mathematics , organic chemistry , extracellular
To compare the pharmacokinetics and tissue distribution of 5-fluorouracil administered intraperitoneally with two isotonic carrier solutions: HAES-steri (neotype 6% hydroxyethyl starch), a novel carrier solution with middle molecular weight and physiologic saline (0.9% sodium chloride solution), a traditional carrier solution for intraperitoneal chemotherapy, in rats.