Open AccessRole of ABCC2 common variants in intrahepatic cholestasis of pregnancy
Author(s) -
Silvia Sookoian,
Gustavo Osvaldo Castaño,
Carlos José Pirola
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2126
Subject(s) - cholestasis of pregnancy , cholestasis , pregnancy , genetic predisposition , medicine , fetus , obstetrics , biology , genetics , disease
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.