Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy | Zendy

Silvia Sookoian | Zendy; Gustavo Castaño | Zendy; Carlos J. Pirola | Zendy

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Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy

Author(s) -

Silvia Sookoian,

Gustavo Castaño,

Carlos J. Pirola

Publication year - 2008

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.14.2126

Subject(s) - cholestasis of pregnancy , cholestasis , pregnancy , genetic predisposition , medicine , fetus , obstetrics , biology , genetics , disease

The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.

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