Open AccessNon-alcoholic fatty liver disease and the metabolic syndrome: An update
Author(s) -
R. Scott Rector,
John P. Thyfault,
Yongzhong Wei,
Jamal A. Ibdah
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.185
Subject(s) - metabolic syndrome , fatty liver , medicine , insulin resistance , adipokine , nonalcoholic fatty liver disease , steatohepatitis , exacerbation , disease , adipose tissue , population , gastroenterology , obesity , bioinformatics , biology , environmental health
Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). NAFLD is estimated to affect approximate 30% of the general US population and is considered the hepatic manifestation of the metabolic syndrome. Recent findings linking the components of the metabolic syndrome with NAFLD and the progression to nonalcoholic steatohepatitis (NASH) will be reviewed; in particular, the role of visceral adipose tissue, insulin resistance, and adipocytokines in the exacerbation of these conditions. While no therapy has been proven effective for treating NAFLD/NASH, common recommendations will be discussed.