Open AccessMutations in components of the Wnt signaling pathway in gastric cancer
Author(s) -
Kai-Feng Pan,
Wan-Guo Liu,
Lian Zhang,
WeiCheng You,
Youyong Lü
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.1570
Subject(s) - axin2 , frameshift mutation , mutation , wnt signaling pathway , missense mutation , microbiology and biotechnology , genetics , biology , carcinogenesis , cancer research , cancer , gene
To explore the contribution of AXIN1, AXIN2 and beta-catenin, components of Wnt signaling pathway, to the carcinogenesis of gastric cancer (GC), we examined AXIN1, AXIN2 exon7 and CTNNB1 (encoding beta-catenin) exon3 mutations in 70 GCs.