Open AccessGastrointestinal stromal tumour of the rectum: Report of a case and review of literature
Author(s) -
Nello Grassi,
Calogero Cipolla,
Adriana Torcivia,
Stefano Mandalà,
Giuseppa Graceffa,
Alessandro Bottino,
Federica Latteri
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.1302
Subject(s) - gist , rectum , medicine , cd117 , biopsy , stromal tumor , differential diagnosis , surgery , radiology , stromal cell , cd34 , pathology , stem cell , biology , genetics
Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CD117 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and non-metastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST.