Open AccessMirna expression profiling of anaplastic thyroid cancer
Author(s) -
Margarita Knyazeva,
Lidia Zabegina,
Elena Sidina,
Aleksey Karizky,
Evgeniya Tsyrlina,
Anna Atrem’eva,
Irina Kuznetsova,
S.L. Vorobyev Vorobyev,
Anastasia Malek
Publication year - 2021
Publication title -
voprosy onkologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 11
eISSN - 2949-4915
pISSN - 0507-3758
DOI - 10.37469/0507-3758-2021-67-1-70-76
Subject(s) - anaplastic thyroid cancer , microrna , thyroid , thyroid cancer , carcinogenesis , cancer research , follicular thyroid cancer , medicine , gene expression profiling , pathology , cancer , bioinformatics , oncology , biology , gene expression , papillary thyroid cancer , gene , genetics
Malignant transformation of follicular epithelium of the thyroid gland is associated with specific alterations of miRNA profile. Evaluation of miRNAs expression changes is being applied for primary or differential diagnostic of thyroid nodes. Anaplastic thyroid cancer (ATC) is relatively rare form of thyroid cancer with high malignant potency and rate of lethality. Investigation of miRNAs role in ATC might provide with soul for development of new diagnostic and therapeutic approaches. Goal: To analyze expression profile of miRNA in ATC and to identify miRNAs involved in pathogenesis of ATC. Material and Methods: Samples of ATC (n.20) and normal thyroid tissue (n. 22) were included in the study, expression levels of 85 cancer-associated miRNAs were analyzed by RT-PCR. Results: Expression of miR-375, miR-1246 and miR-21 is activated while expression of miR-Let7b, miR-125b and miR-181a is suppressed in cells of ATC. Conclusions: Further investigation of miRNA involvement into carcinogenesis of ATC is needed for development of new diagnostic and therapeutic approaches.