Open AccessEffect of metformin on doxorubicin-induced cardiotoxicity in experiment
Author(s) -
Stepan Ionov,
Valentina Orlova,
Natalia Kulbachevskaya
Publication year - 2021
Publication title -
voprosy onkologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 11
eISSN - 2949-4915
pISSN - 0507-3758
DOI - 10.37469/0507-3758-2021-67-1-35-39
Subject(s) - cardiotoxicity , doxorubicin , metformin , medicine , drug , pharmacology , diabetes mellitus , cancer , oncology , chemotherapy , endocrinology
The article provides an overview of the currently known descriptions of the mechanisms and toxic effects of two drugs: doxorubicin, a first-line drug for the treatment of cancer, and the mechanisms of action of Metformin, a drug widely used for the treatment of diabetes mellitus 2. The review made with the usage of NCBI, PubMed and OxfordAcademic presents the analysis of published data on the protective effect of Metformin in its combined use with doxorubicin in an experiment in an attempt to reduce the manifestations of doxorubicin-induced cardiotoxicity.