Open AccessThe molecular mechanisms of multidrug resistance of human glioblastomas
Author(s) -
Alexandr Chernov,
Ирина Балдуева,
Tatyaekhaeva,
Е. С. Галимова,
Diana Alaverdian,
Olga V. Shamova
Publication year - 2021
Publication title -
voprosy onkologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 11
eISSN - 2949-4915
pISSN - 0507-3758
DOI - 10.37469/0507-3758-2021-67-1-20-28
Subject(s) - biology , microrna , angiogenesis , gene , multiple drug resistance , drug resistance , context (archaeology) , transcription factor , signal transduction , cancer research , suppressor , atp binding cassette transporter , genetics , computational biology , bioinformatics , transporter , paleontology
In review discusses the phenomenon of drug resistance of GB in the context of the expression of ABC family transporter proteins and the processes of proliferation, angiogenesis, recurrence and death. The emphasis is on the identifying for molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, tumor suppressor genes and their polymorphic variants (SNPs) for the development and creation of targeted anticancer drugs.