Open AccessRADIOSURGERY OF BRAIN METASTASES: RETROSPECTIVE ANALYSIS OF 5 YEAR RESULTS
Author(s) -
М. Гиршович,
О. И. Пономарева,
Yu S Melnik,
С. Н. Новиков,
Ye. Khrapovitskaya,
Sergey Kanaev
Publication year - 2020
Publication title -
voprosy onkologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 11
eISSN - 2949-4915
pISSN - 0507-3758
DOI - 10.37469/0507-3758-2020-66-5-540-548
Subject(s) - radiosurgery , medicine , lung cancer , retrospective cohort study , breast cancer , melanoma , cancer , brain metastasis , lung , radiology , oncology , radiation therapy , metastasis , cancer research
In 5 year 180 patients (89 men and 91 women) underwent radiosurgery of brain metastases. Most patients had breast cancer and less than 5 lesions. Median overall survival (MOS) was 12,5 months, median progression free survival (MPFS) - 6,1 months. Both values were higher in patients with solitary lesions: 22.5 vs 10 months (р=0.00703) and 9 vs 6 months (р=0.02787), respectively.MOS was 18 in women with breast cancer, 12 months in patients with non small cell lung cancer. 8 - with melanoma and only 4 months - for small cell lung cancer. MPFS was significantly shorter for lesions volumes above 15 cm3. In field progression was detected in 37 (2-24 months after treatment) of 180 cases (20,5%). Second radiosurgery was performed in 24 cases.