Open AccessIMMUNOLOGY AND PROSPECTS OF IMMUNOTHERAPY OF THE PRIMARY MALIGNANT BRAIN TUMORS: CELLULAR THERAPY, VIROTHERAPY
Author(s) -
С. А. Кулева,
Aleksandr Druy
Publication year - 2020
Publication title -
voprosy onkologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 11
eISSN - 2949-4915
pISSN - 0507-3758
DOI - 10.37469/0507-3758-2020-66-3-218-222
Subject(s) - virotherapy , oncolytic virus , immunotherapy , brain tumor , medicine , glioma , cancer research , immunology , immune system , pathology
High-grade gliomas (Grade III-IV) are aggressive brain tumor with poor prognosis. Recent investigations are aimed on pathogenic mechanisms of tumor growth on cellular at the molecular-genetic level for the development of effective individualized treatment methods, while the limit of survival benefit of conventional therapeutic options has been already reached. Integration of immunotherapeutic approach (cellular therapy, virotherapy) into treatment schemes of the brain tumors is relevant and promising strategy based on biological features of tumor tissue.