Open AccessEvidence-based anti-viral and immunomodulatory potential of Black cumin (Nigella sativaL.) in COVID-19
Author(s) -
Muhammad Riaz,
Majid Khan,
Rizwan Ahmad,
Lina Hussain AlLehaibi,
Najmur Rahman,
Dandan Dou
Publication year - 2022
Publication title -
boletín latinoamericano y del caribe de plantas medicinales y aromáticas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 21
ISSN - 0717-7917
DOI - 10.37360/blacpma.22.21.2.11
Subject(s) - coronavirus , immune system , adjuvant , virology , pandemic , medicine , traditional medicine , viral shedding , immunology , virus , biology , disease , covid-19 , infectious disease (medical specialty)
Currently, the whole world is facing a life-threatening novel coronavirus 2019 (COVID-19) pandemic. Natural products are well-known for their potential role against viral disease, and some anti-viral agents have been developed to combat these diseases. Herein, the authors investigated the possible effects of this Holy plant Nigella sativaL. (NS), against coronavirus, using evidence-based and mechanistic approaches to conclude the immune-boosting and alleviation of respiratory systemeffects of NS. The pharmacological studies established a prominent role in treating various respiratory, immune systems, cardiovascular, skin, and gastrointestinal disorders. Literature supported the significant anti-viral role and showed an inhibitory role for NS against MHV-A59 CoV (mouse-hepatitis virus–A59) infected Hela, i.e., HeLaCEACAM1a (HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a) cell. NS is a safe herbal product or dietary supplement and could be an effective and affordable community adjuvant treatment for coronavirus in the current scenario.