Open AccessComparative study of the antifungal activity of sequential extracts of Fuchsia lycioides against Candida sp.
Author(s) -
Marcela Brito,
Ana Maturana,
Iván Montenegro,
Bastián Said,
Ana Isabel Morales,
Valeska Calderón,
Susana Flores,
Manuel Arcindo García Martínez,
Alejandro Madrid
Publication year - 2022
Publication title -
boletín latinoamericano y del caribe de plantas medicinales y aromáticas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 21
ISSN - 0717-7917
DOI - 10.37360/blacpma.22.21.1.08
Subject(s) - ethyl acetate , phytol , maceration (sewage) , candida albicans , traditional medicine , terpenoid , chemistry , antifungal , itraconazole , biology , botany , chromatography , microbiology and biotechnology , medicine , materials science , composite material
The genus Fuchsia is generally used in herbal preparations to treat conditions caused by microorganisms. Based on the popular use of this type of plants, the objective of this study was to obtain sequential extracts of increasing polarity from the branches of Fuchsia lycioides by maceration at room temperature and by the Soxhlet method at 60ºC, to later evaluate the antifungal capacity of the extracts against different clinical isolates of the Candida genus. The ethyl acetate extract exhibited strong anti-fungal activity, selectively inhibiting C. albicans strains with MIC and CMF values of 10 and 15 µg/mL, respectively; comparable with the drug itraconazole®. The analysis of the extract by GC-MS showed a high concentration of terpenoids (mainly phytol) and phenylpropanoids (mainly cinnamic acid), possibly responsible for the antifungal activity of the ethyl acetate extract of F. lycioides.