Open AccessAntinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex
Author(s) -
Renan Marinho Braga,
Humberto Hugo Nunes de Andrade,
Humberto de Carvalho Aragao Neto,
Ryldene Marques Duarte da Cruz,
Davidson Barbosa Assis,
Luiz Henrique Agra,
Sandra Rodriguez-Mascarenhas,
Liana Clébia de Morais Pordeus,
Lucindo J. QuintansJúnior,
Reinaldo Nóbrega de Almeida
Publication year - 2021
Publication title -
boletín latinoamericano y del caribe de plantas medicinales y aromáticas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 21
ISSN - 0717-7917
DOI - 10.37360/blacpma.21.20.2.13
Subject(s) - lippia , traditional medicine , nociception , medicine , population , essential oil , pharmacology , chemistry , food science , receptor , environmental health
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great suffering and disability and the drugs most often used have undesirable side effects. We also evaluated whether the inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able to improve the antinociceptive activity of the EOLp alone. Data were evaluated by analysis of variance (ANOVA), followed by Tukey’s test. Differences were considered significant if p<0.05. EOLp presented better antinociceptive effect when compared to the EOLp/β-CD inclusion complex. Thus, cyclodextrins appear not to be efficient for essential oils with peroxide substances. However, in peritonitis, EOLp reduced total leucocyte migration and IL-1β levels in the peritoneal fluid, which confirmed its anti-inflammatory effect. The observed effects suggest that EOLp is the best promising option for the treatment of inflammation and pain-related disorders.