Open AccessRe-profiling of drugs in radiological pharmacology: N-acetylcysteine
Author(s) -
Nikolay Kolotilov Sc.D.,
V. Vojtko
Publication year - 2019
Publication title -
radiation diagnostics, radiation therapy
Language(s) - English
Resource type - Journals
eISSN - 2707-0700
pISSN - 2707-0697
DOI - 10.37336/2707-0700-2019-4-7
Subject(s) - medicine , acetylcysteine , expectorant , oxidative stress , pharmacology , disease , radiation therapy , antioxidant , surgery , pathology , biochemistry , chemistry
Acetylcysteine (ACC) is a mucolytic, expectorant medicine with antioxidant, anti-inflammatory, anti-infective, radioprotective, pulmonary protective, anticarcinogenic and antitoxic effects. The review describes the examples of ACC application in radiation diagnostics and therapy for pharmacological radioprotection of the patient’s body and organs. ACC mitigates the negative effects of radiation therapy on the healing of a postoperative wound by reducing oxidative stress markers. ACC significantly reduces the x-ray density of breast tissue, that is, reduces the cancer risk. It has been proven that intravenous and oral administration of ACC prevents nephropathy caused by radiopaque agents. The clinical effectiveness of ACC in the treatment of acute and chronic neurological syndromes of radiation disease is assumed.