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Experience on using Resveratrol in the comprehensive treatment of patients with psoriasis
Author(s) -
Елена Безега,
Ирина Борисовна Попова,
Е. С. Васильева,
Николай Алексеевич Дудченко,
Алексей Гладков
Publication year - 2019
Publication title -
dermatovenerologiâ, kosmetologiâ, seksopatologiâ
Language(s) - English
Resource type - Journals
ISSN - 1561-3607
DOI - 10.37321/dermatology.2019.3-4-09
Subject(s) - psoriasis , resveratrol , antioxidant , dyslipidemia , blood lipids , medicine , pharmacology , chemistry , albumin , hemoglobin , cholesterol , biochemistry , disease , immunology
This work is devoted to the search for new methods of treatment because of the high level of the prevalence of psoriasis. This article describes the relationship between the dependence of the clinical picture and lipid peroxi­dation in patients with psoriasis and the advisability of including drugs with antioxidant properties in the treat­ment. LOPs regulate cell proliferation and cell membrane permeability. In patients with psoriasis in the blood se­rum, there is an increase in the level of lipid metabolism products, namely cholesterol, triglycerides and free fatty acids, as well as a change in the ratio of the fractional content of phospholipids in erythrocyte membranes. Therefore, one of the most characteristic manifestations of the activity of the psoriatic process is dyslipidemia. Given the pathogenic mechanisms of the development of this disease and increase effectiveness in complex treatment, it is advisable to include drugs with antioxidant properties. Antioxidants are biological substances that can interact with various forms of free radicals and lead to their inhibition or complete blockage. The study was conducted with the addition of Resveratrol to standard treatment regimens for psoriasis. The scope of labora­tory studies included the diagnosis of changes in a bio­chemical blood test collected on an empty stomach in the morning, namely, to study the content of: total protein, albumin, bilirubin, low and high density lipids, phospho­lipids, cholesterol, alanine aminotransferase, aspartate aminotransferase. After the treatment, the effectiveness of the treatment of complex therapy with the addition of antioxidants has been proved.

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