Chronophered approach to appointment of patients with alergodromatosis of antioxidant drugs

Objective - to increase the efficiency of treatment of pa­tients with allergic dermatitis by using chronodermined antioxidant drugs, taking into account the daily rhythms of the parameters of prooxidant antioxidant homeostasis. Materials and methods: 73 patients with allergic derma­titis (eczema, allergic and atopic dermatitis) were exam­ined, which determined the circadian (daily) rhythms of the parameters of prooxidant-antioxidant homeostasis. Results and discussion. In patients with allergic der­matitis, an increase in the mesor and amplitude of ma­lonic aldehyde, the fractions of oxidative modification of proteins and mediomolecular peptides with acrophase in the evening hours, as well as the reduction of the mesor of reduced glutathione and ceruloplasmin with batifase in evening hours, has been established, indicating activa­tion and growth during free radical oxidation processes lipids and proteins against the background of a decrease in the activity of antioxidant flora, which substantiates the chronoderminable purpose of such a patient with antioxidant drugs. Conclusion: Chronodetermined ap­pointment in the complex treatment of allergic dermati­tis antioxidant drugs accelerates the regression of their clinical manifestations, reduces the timing of treatment of patients, as well as helps to normalize their prooxidant antioxidant homeostasis.