Chronophered approach to appointment of patients with alergodromatosis of antioxidant drugs

Objective - to increase the efficiency of treatment of patients with allergic dermatitis by using chronodermined antioxidant drugs, taking into account the daily rhythms of the parameters of prooxidant antioxidant homeostasis. Materials and methods: 73 patients with allergic dermatitis (eczema, allergic and atopic dermatitis) were examined, which determined the circadian (daily) rhythms of the parameters of prooxidant-antioxidant homeostasis. Results and discussion. In patients with allergic dermatitis, an increase in the mesor and amplitude of malonic aldehyde, the fractions of oxidative modification of proteins and mediomolecular peptides with acrophase in the evening hours, as well as the reduction of the mesor of reduced glutathione and ceruloplasmin with batifase in evening hours, has been established, indicating activation and growth during free radical oxidation processes lipids and proteins against the background of a decrease in the activity of antioxidant flora, which substantiates the chronoderminable purpose of such a patient with antioxidant drugs. Conclusion: Chronodetermined appointment in the complex treatment of allergic dermatitis antioxidant drugs accelerates the regression of their clinical manifestations, reduces the timing of treatment of patients, as well as helps to normalize their prooxidant antioxidant homeostasis.