Safety Assessment of Combination of Tinospora crispa Extract, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum dan Momordica charantia in Hepar and Renal Function

Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygiumpolyanthum and Momordica charantia contain phenolics and flavonoidswhich are rich in benefits. Phenolic compounds are compounds that have anaromatic ring with one or more hydroxy groups, compounds derived fromplants that have the same characteristics, namely aromatic rings containingone or more hydroxyl groups. Herbal plants, which are rich in phenoliccompounds, have the efficacy, among others, as antioxidants, anti-inflammatory, antimicrobial, anti-fungal and prevents tumor growth. Theacute toxicity test is a procedure designed to determine the median lethal doseof a substance and its possible mechanism of action and target organs. Insimple terms, toxicity can be defined as the ability of a compound that cancause harmful effects or deviate from the biological mechanism in anorganism.