Open AccessCorrelation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review
Author(s) -
Yuda Nabella Prameswari,
Dwi Anita Suryandari
Publication year - 2022
Publication title -
bioscientia medicina
Language(s) - English
Resource type - Journals
ISSN - 2598-0580
DOI - 10.37275/bsm.v6i4.484
Subject(s) - autophosphorylation , epidermal growth factor receptor , tyrosine kinase , epidermal growth factor , receptor tyrosine kinase , cancer research , microbiology and biotechnology , signal transduction , biology , growth factor receptor , grb2 , platelet derived growth factor receptor , erbb3 , ror1 , growth factor receptor inhibitor , cyclin dependent kinase 8 , growth factor , receptor , kinase , protein kinase a , biochemistry , notch signaling pathway
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.