Open AccessPathogenesis Aspects of Microvascular Complications in Diabetic Retinopathy: Narrative Literature Review
Author(s) -
Olga SimóServat,
Cristina Hernández,
Rafael Simó
Publication year - 2022
Publication title -
archives of the medicine and case reports
Language(s) - English
Resource type - Journals
ISSN - 2747-2051
DOI - 10.37275/amcr.v3i2.197
Subject(s) - polyol pathway , glycation , pathogenesis , diabetes mellitus , diabetic retinopathy , medicine , oxidative stress , retinopathy , protein kinase c , advanced glycation end product , endocrinology , signal transduction , biochemistry , biology , aldose reductase
Chronic hyperglycemic conditions in diabetes mellitus can cause changes that result in chronic complications, both macrovascular and microvascular. There are several mechanisms thought to cause microvascular damage and retinopathy in diabetes, namely the polyol pathway, formation of advanced glycation end products (AGE), activation of protein kinase C (PKC), oxidative stress, and increased activity of the hexosamine pathway.