Open AccessRegulation of Glucose Metabolism in Hepatocarcinogenesis by MicroRNAs
Author(s) -
Ryan Reyes,
Tasneem Motiwala,
Samson T. Jacob
Publication year - 2014
Publication title -
gene expression
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 46
eISSN - 1555-3884
pISSN - 1052-2166
DOI - 10.3727/105221614x13919976902093
Subject(s) - glycolysis , microrna , gluconeogenesis , pentose phosphate pathway , metabolism , anaerobic glycolysis , carbohydrate metabolism , metabolic pathway , mechanism (biology) , microbiology and biotechnology , chemistry , biology , biochemistry , cancer research , computational biology , gene , epistemology , philosophy
In the past decade, considerable effort has been made in elucidating the mechanism underlying the high level of aerobic glycolysis in cancer cells. While some recent studies have attempted to address this issue, the potential role of microRNAs in this process has not been explored until recently. These studies have demonstrated involvement of just five deregulated miRNAs in glucose metabolism in hepatocarcinogenesis. This review discusses the metabolic significance of these miRNAs in hepatoceullular carcinoma, their targets in glycolysis, gluconeogenesis, and pentose phosphate pathways, and provides an insight into the therapeutic potential of targeting specific miRNAs.