Open AccessHeme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway in Murine Mammary Carcinoma
Author(s) -
Qiang Li,
Qi Liu,
Wanpeng Cheng,
Huiyan Wei,
Wenqian Jiang,
Erhu Fang,
Yuan Yu,
Jianfeng Jin,
Chaoxia Zou
Publication year - 2019
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504018x15415906335771
Subject(s) - metastasis , slug , cancer research , epithelial–mesenchymal transition , heme oxygenase , breast cancer , mammary tumor , cancer , in vivo , mammary gland , carcinoma , breast carcinoma , biology , medicine , heme , pathology , enzyme , microbiology and biotechnology , biochemistry
Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated indices for epithelial‐mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated. The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, the Notch1/Slug pathway is found to mediate an antimetastasis role of HO-1 in mouse mammary carcinoma. In conclusion, since HO-1/Notch1/Slug axis plays an important role in breast cancer metastasis, induction of HO-1 could be used as a potential therapeutic strategy for breast cancer treatment.