Open AccessExpression and Function of Long Noncoding RNA NONHSAT129183 in Papillary Thyroid Cancer
Author(s) -
Jian Ding,
Fuqing Wang,
Tiangang Xiang,
Meng Qiao
Publication year - 2018
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504018x15152037713570
Subject(s) - gene silencing , papillary thyroid cancer , long non coding rna , biology , cancer research , cell growth , thyroid cancer , downregulation and upregulation , metastasis , cancer , cell , pathogenesis , cell migration , tumor progression , pathology , medicine , gene , immunology , genetics
The aberrant expression of long noncoding RNAs (lncRNAs) is implicated in cancer development and progression. This study was aimed to investigate the expression and clinical significance of lncRNA NONHSAT129183 in papillary thyroid cancer (PTC), and to explore its roles in PTC cell proliferation, migration, and invasion. Our results demonstrate that lncRNA NONHSAT129183 is upregulated in human PTC tissues when compared with that in adjacent noncancerous thyroid tissue. Moreover, its expression is correlated with tumor size, lymph node metastasis, and TNM stage in PTC patients. lncRNA NONHSAT129183 silencing also significantly suppressed cell proliferation, migration, and invasion in PTC cell lines. In conclusion, our results suggest that lncRNA NONHSAT129183 plays a critical role in the regulation of PTC cell proliferation, migration, and invasion, providing new insights into PTC pathogenesis.