Open AccessOverexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells
Author(s) -
Erkun Guo,
Hongjiang Liu,
Xiaopeng Liu
Publication year - 2017
Publication title -
oncology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 57
eISSN - 1555-3906
pISSN - 0965-0407
DOI - 10.3727/096504016x14747335734344
Subject(s) - glioma , in vitro , cancer research , biology , in vivo , cell growth , sonic hedgehog , cell culture , hedgehog signaling pathway , signal transduction , cell migration , cell , microbiology and biotechnology , biochemistry , genetics
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed glioma cell migration and invasion in vitro. Furthermore, we found that the Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. In light of the results obtained from our study, SCUBE2 may be regarded as a potential therapeutic target for glioma.